Mice Transplanted with CD34 Cells from Human Cord Blood Show Low Levels of Intestinal Engraftment and Are Resistant to Rectal Transmission of Human Immunodeficiency Virus
نویسندگان
چکیده
Published Ahead of Print 8 October 2008. 2008, 82(24):12145. DOI: 10.1128/JVI.01105-08. J. Virol. Thomas Brunner and Roberto F. Speck Erika Schlaepfer, Nadine Gehre, Stephan Regenass, Ursula Hofer, Stefan Baenziger, Mathias Heikenwalder, Immunodeficiency Virus Resistant to Rectal Transmission of Human Levels of Intestinal Engraftment and Are Cells from Human Cord Blood Show Low + Mice Transplanted with CD34 − / − c γ − / − RAG2
منابع مشابه
RAG2-/- gamma(c)-/- mice transplanted with CD34+ cells from human cord blood show low levels of intestinal engraftment and are resistant to rectal transmission of human immunodeficiency virus.
Rectal transmission is one of the main routes of infection by human immunodeficiency virus type 1 (HIV-1). To efficiently study transmission mechanisms and prevention strategies, a small animal model permissive for rectal transmission of HIV is mandatory. We tested the susceptibility of RAG2(-/-)gamma(c)(-/-) mice transplanted with human cord blood hematopoietic stem cells to rectal infection w...
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